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Lipoprotein lipase is an enzyme which hydrolyzes lipids in lipoproteins, like those found in chylomicrons and very low density lipoproteins (VLDL), into three fatty acids and one glycerol molecule. It requires Apo-CII as a cofactor.

LPL deficiency leads to hypertriglyceridemia (elevated levels of triglycerides).

Lipoprotein lipase is specifically found in endothelial cells lining the capillaries. Insulin is known to enhance LPL synthesis in adipocytes and its placement in the capillary endothelium.

High fat diets have been shown to cause tissue specific overexpression of LPL: this has been implicated in tissue specific insulin resistance and consequent development of type 2 diabetes mellitus



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